THERAPY DOSSIER · th-ffa70e9a496e

Ex vivo expanded human or rat mesenchymal stromal cells, with or without priming

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02033525 ↗Injury indicationPHASE1/PHASE2completed

Phase I-IIa Trial of Intraarticular Autologous Mesenchymal Cells (XCEL-M-ALPHA) for Meniscus Injury

Chronic Meniscal Injury

Enrolment: 20 · Results not recorded

NCT02630836 ↗Injury indicationPHASE1/PHASE2withdrawn

Pilot Trial of ex Vivo Expanded Allogenic Adult Stem Cells With Allogenic Human Bone Tissue (XCEL-MT-OSTEO-BETA) in Proximal Femur Fractures

Femoral Neck Fracture

Enrolment: 0 · Results not recorded

NCT02805855 ↗PHASE1completed

Safety and Feasibility of Autologous Culture Expanded Adipose Derived Mesenchymal Stromal Cells in Painful Knee Osteoarthritis

Osteoarthritis, Knee

Enrolment: 15 · Results not recorded

NCT03461458 ↗PHASE1terminated

Phase I Study of Autologous, Culture-Expanded Adipose-Derived Mesenchymal Stromal Cells in Painful Degenerative Disc Disease

Degenerative Disc Disease

Enrolment: 1 · Results not recorded

NCT04815213 ↗PHASE1active not recruiting

The Use of Expanded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure: Phase I Clinical Trial

Premature Ovarian Failure

Enrolment: 10 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29223534 ↗2017Mixed findings

Systemic recovery and therapeutic effects of transplanted allogenic and xenogenic mesenchymal stromal cells in a rat blunt chest trauma model.

RatOtherWistarMaleSingle dose; cell number not stated in the abstractImmediately after induction of blunt chest trauma

Model: Blunt chest trauma (TxT) causing lung contusion and acute lung injury

Human mesenchymal stromal cells reduced the injury score at 24 h by at least 50 per cent versus untreated trauma and lowered pro-inflammatory cytokines and chemokines while raising TNFAIP6. Rat mesenchymal stromal cells did not show these therapeutic effects except for TNFAIP6. By 5 days cytokine l…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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