Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome.
RatRadiationMaleIntraperitoneal5000 IU/kg24 hours after irradiation
Model: Single sublethal dose of 7 Gy gamma total body irradiation
Erythropoietin improved 30-day survival, alleviated myelosuppression and pancytopenia, restored bone marrow and spleen cellularity and splenic function, reduced hepatotoxicity biomarkers and oxidative stress, and prevented hepatic and splenic apoptosis via alpha-7-nAChR-JAK-2/STAT-3-Nrf-2 signallin…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.