Lysophosphatidic acid protects against acetaminophen-induced acute liver injury.
MouseChemical/toxinC57BL/6Intraperitoneal4 mg/kg LPA; N-acetylcysteine comparator 150 mg/kg30 min before acetaminophen, or therapeutically 1 h or 3 h after acetaminophen
Model: Acetaminophen overdose 400 mg/kg by oral gavage after a 16 h fast, inducing acute liver injury
LPA reduced hepatic necrosis, serum AST and ALT and TUNEL-positive cells, restored glutathione at 1 to 6 h, lowered TNF-alpha and IL-1beta and raised 72 h survival to 100% versus 10% in vehicle controls. Therapeutic dosing at 1 or 3 h after acetaminophen gave 75% survival versus 0%. Protection pers…
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