Evidence & regulatory context
- Mechanism
- Lysophosphatidic acid (LPA) is an endogenous bioactive phospholipid signalling through LPA1-LPA6 G-protein-coupled receptors. No confident ChEMBL drug/compound entity is returned for the name 'lysophosphatidic acid' (it denotes a family of acyl species rather than a single curated molecule), so resolved=false and ChEMBL fields are empty. No human trial administers LPA as a therapy: the 10 ClinicalTrials.gov keyword hits are LPA1-antagonist programmes (PIPE-791, BMS-986020), LPA1 PET ligands (18F-BMS-986327) and LPA biomarker studies, so to_trial is recorded as false and the trial list left empty.
- Target
- Not recorded
- Injury models
- Chemical/toxin · Endotoxin/LPS
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseChemical/toxinC57BL/6Intraperitoneal4 mg/kg LPA; N-acetylcysteine comparator 150 mg/kg30 min before acetaminophen, or therapeutically 1 h or 3 h after acetaminophen
Model: Acetaminophen overdose 400 mg/kg by oral gavage after a 16 h fast, inducing acute liver injury
LPA reduced hepatic necrosis, serum AST and ALT and TUNEL-positive cells, restored glutathione at 1 to 6 h, lowered TNF-alpha and IL-1beta and raised 72 h survival to 100% versus 10% in vehicle controls. Therapeutic dosing at 1 or 3 h after acetaminophen gave 75% survival versus 0%. Protection pers…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
MouseEndotoxin/LPSC57BL/6Intraperitoneal5 mg/kg1 h before lipopolysaccharide injection (pre-treatment)
Model: Lipopolysaccharide (endotoxin)-induced acute kidney injury, assessed 24 h after LPS
LPA 18:1 pre-treatment reduced LPS-induced elevation of plasma urea and creatinine, attenuated renal inflammatory cytokine upregulation, preserved PGC-1alpha and haem oxygenase-1 expression and mitochondrial ultrastructure, and reduced cytokine induction in macrophages in vitro.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
