Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities.
RatIschaemia-reperfusionRenalWistarMaleAdministered before induction of ischaemia/reperfusion
Model: Unilateral renal ischaemia by clamping the left renal artery for 1 h followed by 24 h reperfusion
Both leaf and bark extracts reduced lactate dehydrogenase, creatinine and blood urea nitrogen, restored glutathione and Nrf2 and lowered TNF-alpha, NF-kappaB, IL-6 and caspase-3. The two extracts had similar chemical profiles with 42 identified compounds, flavonoids predominating, and the authors p…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.