Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 1
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
The Effect of Urox (Crateva, Horsetail and Lindera Combination) in the Treatment of Overactive Bladder and Urinary Incontinence
Overactive Bladder · Urinary Incontinence · Urinary Frequency or Urgency Adverse Event · Nocturia
Enrolment: 150 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionRenalWistarMaleAdministered before induction of ischaemia/reperfusion
Model: Unilateral renal ischaemia by clamping the left renal artery for 1 h followed by 24 h reperfusion
Both leaf and bark extracts reduced lactate dehydrogenase, creatinine and blood urea nitrogen, restored glutathione and Nrf2 and lowered TNF-alpha, NF-kappaB, IL-6 and caspase-3. The two extracts had similar chemical profiles with 42 identified compounds, flavonoids predominating, and the authors p…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.