Inhibition of canonical WNT signaling pathway by beta-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12.
MouseChemical/toxinC57BL/6Male
Model: Carbon tetrachloride-induced acute liver injury in mice, with in vitro TGF-beta-activated 3T3 fibroblasts, LX2 cells and primary human hepatic stellate cells
ICG-001 significantly attenuated collagen accumulation and hepatic stellate cell activation in vivo and markedly reduced macrophage infiltration, intrahepatic inflammation and angiogenesis. CXCL12 was suppressed both in vitro and in vivo, and Wnt-regulated CXCL12 secretion from activated stellate c…
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