THERAPY DOSSIER · th-27549291eb0a

ICG-001

Drug · CBP/beta-catenin inhibitor (INHIBITOR); clinical analog PRI-724/OP-724

Evidence & regulatory context

Mechanism: CBP/beta-catenin inhibitor (INHIBITOR); clinical analog PRI-724/OP-724
Target: CREB-binding protein / beta-catenin (CHEMBL4665593)
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4297813 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: ICG-001; (S,S)-ICG-001; PRI-724; Foscenvivint; OP-724
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02413853 ↗PHASE2withdrawn

Randomized Phase II Trial of mFOLFOX6/Bevacizumab With or Without PRI-724 in Metastatic Colorectal Cancer

Colorectal Adenocarcinoma

Enrolment: 0 · Results not recorded

NCT02195440 ↗PHASE1completed

Open Label, Single Arm, Dose Escalation Phase 1 Trial of PRI-724 in HCV-induced Cirrhosis

Hepatitis C Virus-infected Cirrhosis

Enrolment: 14 · Results not recorded

NCT04688034 ↗PHASE1completed

Phase I Clinical Trial of CBP/Beta-catenin Inhibitor OP-724 in Liver Cirrhosis (HIV/HCV Co-infection)

Liver Cirrhosis

Enrolment: 5 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29217140 ↗2017Reported benefit

Inhibition of canonical WNT signaling pathway by beta-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12.

MouseChemical/toxinC57BL/6Male

Model: Carbon tetrachloride-induced acute liver injury in mice, with in vitro TGF-beta-activated 3T3 fibroblasts, LX2 cells and primary human hepatic stellate cells

ICG-001 significantly attenuated collagen accumulation and hepatic stellate cell activation in vivo and markedly reduced macrophage infiltration, intrahepatic inflammation and angiogenesis. CXCL12 was suppressed both in vitro and in vivo, and Wnt-regulated CXCL12 secretion from activated stellate c…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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