Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam.
RatTBIControlled cortical impactSprague-DawleyMalen = 62 rats analysed of 67 enrolled: TBI plus lorazepam 0.1 mg/…Intraperitoneal0.1, 1.0 or 2.0 mg/kgCommencing 24 h after controlled cortical impact or sham injury
Model: Controlled cortical impact of 2.8 mm tissue deformation at 4 m/s through a 6 mm right hemisphere craniotomy under isoflurane anaesthesia, with sham surgery controls
None of the three doses impaired recovery relative to vehicle. The 2.0 mg/kg group performed better than vehicle and than the 0.1 and 1.0 mg/kg groups on beam-walk, beam-balance and water maze acquisition, while the 0.1 and 1.0 mg/kg groups did not differ from vehicle on any endpoint. Probe trial r…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.