THERAPY DOSSIER · th-eedd5b7c5f5c

Lorazepam

Drug · GABA-A receptor positive allosteric modulator (benzodiazepine site)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: GABA-A receptor positive allosteric modulator (benzodiazepine site)
Target: GABA-A receptor (CHEMBL2093872)
Injury models: TBI
Reported indication: Not recorded
First approval: 1977
Development stage: Not recorded
ChEMBL record: CHEMBL580 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Lorazepam; Ativan; Temesta; Loreev XR
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06370442 ↗PHASE3unknown

Intranasal Dexmedetomidine vs Standard of Care (incl. Lorazepam) for ED Procedural Sedation in Older Adults

Altered Mental Status

Enrolment: 60 · Results not recorded

NCT03756038 ↗PHASE2terminated

Single Dose Benzodiazepines (Lorazepam) to Reduce Distress and Opiate Need in Emergency Department

Acute Pain

Enrolment: 1 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29203336 ↗2017Mixed findings

Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam.

RatTBIControlled cortical impactSprague-DawleyMalen = 62 rats analysed of 67 enrolled: TBI plus lorazepam 0.1 mg/…Intraperitoneal0.1, 1.0 or 2.0 mg/kgCommencing 24 h after controlled cortical impact or sham injury

Model: Controlled cortical impact of 2.8 mm tissue deformation at 4 m/s through a 6 mm right hemisphere craniotomy under isoflurane anaesthesia, with sham surgery controls

None of the three doses impaired recovery relative to vehicle. The 2.0 mg/kg group performed better than vehicle and than the 0.1 and 1.0 mg/kg groups on beam-walk, beam-balance and water maze acquisition, while the 0.1 and 1.0 mg/kg groups did not differ from vehicle on any endpoint. Probe trial r…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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