Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction.
MixedHaemorrhage/shockControlledWistar-KyotoMalen = In vivo Tubastatin A n=6, vehicle n=4, normal control n=370 mg/kg in vivo prepared in DMSO at 1 uL per gram bodyweig…After 40 per cent blood volume withdrawal over 10 min plus 30 min of unresuscit…
Model: Sub-lethal unresuscitated haemorrhagic shock: 40 per cent of estimated total blood volume withdrawn over 10 min via femoral artery catheter followed by 30 min of unresuscitated shock, euthanasia 6 h after haemorrhage; in vitro anoxic incubation of endothelial monolayers in glucose-free medium
Tubastatin A significantly reduced haemorrhage-induced acute lung injury score (1 versus 3.25 for vehicle, p=0.032) and in vitro prevented anoxia-induced hyperpermeability, HIF-1alpha induction and glycocalyx shedding
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