Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other · Haemorrhage/shock
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- Not recorded
- Synonyms
- TUBASTATIN-A; TUBASTATIN A; TUBASTATIN A BASE
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatOtherSprague-Dawley (adult albino; primary cortical neurons from P1 pups)Female for in vivo optic nerve transectionn = n = 3 retinas per group for cilia quantification; n = 4 ret…Intraocular (intravitreal) injection into the vitreous chamber4 microL of tubastatin A at 6.8 microg/microL or Aurora Kin…Intravitreal drug at 3 and 10 days after surgery per the Methods (stated as 3 a…
Model: Optic nerve transection under isoflurane anaesthesia, with the nerve cut within 2 mm of the back of the eye; in vitro models used 5 or 8 hours of hypoxia followed by 24 hours of normoxia, and 50 microM etoposide for 24 hours
Intravitreal tubastatin A and Aurora Kinase A Inhibitor I each significantly increased retinal ganglion cell survival at 14 days after optic nerve transection compared with DMSO, and shRNA knockdown of HEF1, PLK1 or Kif2a improved survival, with NDE1 knockdown improving survival only at middle and…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
MixedHaemorrhage/shockControlledWistar-KyotoMalen = In vivo Tubastatin A n=6, vehicle n=4, normal control n=370 mg/kg in vivo prepared in DMSO at 1 uL per gram bodyweig…After 40 per cent blood volume withdrawal over 10 min plus 30 min of unresuscit…
Model: Sub-lethal unresuscitated haemorrhagic shock: 40 per cent of estimated total blood volume withdrawn over 10 min via femoral artery catheter followed by 30 min of unresuscitated shock, euthanasia 6 h after haemorrhage; in vitro anoxic incubation of endothelial monolayers in glucose-free medium
Tubastatin A significantly reduced haemorrhage-induced acute lung injury score (1 versus 3.25 for vehicle, p=0.032) and in vitro prevented anoxia-induced hyperpermeability, HIF-1alpha induction and glycocalyx shedding
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
