Use of Copaifera multijuga for acute corneal repair after chemical injury: A clinical, histopathological and toxicogenetic study.
RatChemical/toxinWistarMale (MeSH indexed)Topical ocular instillation0.1 per cent and 0.5 per cent oleoresin eye dropsAfter alkali-induced ulcer induction
Model: Superficial corneal ulcer induced with alkali in the left eye
Copaifera multijuga eye drops significantly improved ulcer reduction and corneal stromal thickness compared with untreated injury and showed no cytotoxicity or genotoxicity, but did not significantly reduce alkali-induced corneal epithelial damage, similar to the reference drugs
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