THERAPY DOSSIER · th-e5374a94b4dd

Eye drops containing Copaifera multijuga Hayne oleoresin, copaiba oil

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06708702 ↗PHASE2withdrawn

Phase II Study of Copaiba-based Mouthwash in Oral Mucositis Prevention and Treatment in Oral Cancer Patients During Radiotherapy

Oral Mucositis

Enrolment: 0 · Results not recorded

NCT05308732 ↗PHASE1active not recruiting

Phase I Multiple Ascending Dose Study of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

Head and Neck Neoplasms · Mucositis Oral

Enrolment: 20 · Results not recorded

NCT06066671 ↗NAcompleted

Effect of an Experimental Gel Based on Copaiba Oil Resin in Reducing Post-bleaching Tooth Sensitivity

Tooth Bleaching Pain

Enrolment: 75 · Results not recorded

NCT05021146 ↗NAunknown

Essential Oil (Topical Copaiba) for Chronic Low Back Pain

Chronic Low-back Pain

Enrolment: 300 · Results not recorded

NCT06872749 ↗NAcompleted

Effect of an Experimental Gel Containing Copaiba Oil-resin in the Control of Dentin Hypersensitivity

Dentin Sensitivity

Enrolment: 75 · Results not recorded

NCT06931977 ↗NAcompleted

Wellness and Epigenetic Impact of a Natural Product Supplement System With Copaiba Softgels

Healthy

Enrolment: 97 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29169733 ↗2017Mixed findings

Use of Copaifera multijuga for acute corneal repair after chemical injury: A clinical, histopathological and toxicogenetic study.

RatChemical/toxinWistarMale (MeSH indexed)Topical ocular instillation0.1 per cent and 0.5 per cent oleoresin eye dropsAfter alkali-induced ulcer induction

Model: Superficial corneal ulcer induced with alkali in the left eye

Copaifera multijuga eye drops significantly improved ulcer reduction and corneal stromal thickness compared with untreated injury and showed no cytotoxicity or genotoxicity, but did not significantly reduce alkali-induced corneal epithelial damage, similar to the reference drugs

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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