Platelets derived from fresh and cold-stored whole blood participate in clot formation in rats with acute traumatic coagulopathy.
RatHaemorrhage/shockUncontrolledSprague-Dawley, including green fluorescent protein transgenic donorsMaleTransfusion, intravenousResuscitation 1 hour after trauma
Model: Polytrauma and haemorrhage producing acute traumatic coagulopathy, with a liver incision made after transfusion and tissue collected 10 min after that injury
Compared with fresh whole blood, cold-stored whole blood showed 35 per cent lower aggregation to adenosine diphosphate, 20 per cent lower aggregation to protease-activated receptor-4 and 25 per cent shorter clotting time with higher platelet activation and clearance, yet platelets from both product…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.