THERAPY DOSSIER · th-3d8602dfda43

Fresh whole blood and cold-stored whole blood from green fluorescent protein transgenic rats

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04988620 ↗Injury indicationNAunknown

Cold Stored Whole Blood in Treatment of Bleeding in Patients Undergoing Cardiothoracic Surgery

Bleeding

Enrolment: 80 · Results not recorded

NCT01892670 ↗Injury indicationNAcompleted

Storage Temperature and Quality of Leucoreduced Whole Blood

Trauma · Austere Environment · Blood Bank · Buddy Transfusion

Enrolment: 87 · Results not recorded

NCT00176124 ↗PHASE4completed

Leukocyte Depletion of Autologous Whole Blood: Impact on Perioperative Infection Rate and Length of Hospital Stay for Hip Arthroplasty Patients

Infection · Bacterial Infection · Sepsis

Enrolment: 1089 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29168170 ↗2017Reported benefit

Platelets derived from fresh and cold-stored whole blood participate in clot formation in rats with acute traumatic coagulopathy.

RatHaemorrhage/shockUncontrolledSprague-Dawley, including green fluorescent protein transgenic donorsMaleTransfusion, intravenousResuscitation 1 hour after trauma

Model: Polytrauma and haemorrhage producing acute traumatic coagulopathy, with a liver incision made after transfusion and tissue collected 10 min after that injury

Compared with fresh whole blood, cold-stored whole blood showed 35 per cent lower aggregation to adenosine diphosphate, 20 per cent lower aggregation to protease-activated receptor-4 and 25 per cent shorter clotting time with higher platelet activation and clearance, yet platelets from both product…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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