Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?
RatOtherSprague-Dawley (Crl:CD(SD))Malen = 228 rats total across 12 groups, of which 184 were operated…Subcutaneous, oral and local wound irrigationBuprenorphine 0.1 mg/kg subcutaneously or 1.0 mg/kg orally…Subcutaneous drugs given during anaesthesia before incision; oral buprenorphine…
Model: Spared nerve injury: common peroneal and tibial branches of the sciatic nerve tightly ligated with 5-0 Prolene and sectioned distal to the ligation with about 2 mm of distal stump removed, sural nerve left intact
No analgesic regimen altered the development of mechanical allodynia after spared nerve injury, but the high-dose combination caused severe adverse effects including peritonitis and increased wound dehiscence, and 72-hour buprenorphine regimens reduced food intake and bodyweight gain
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