THERAPY DOSSIER · th-9161445ae293

Buprenorphine, carprofen and a lidocaine plus bupivacaine local anaesthetic mixture, alone and in combination

Drug · Partial mu opioid receptor agonist with kappa opioid receptor activity; ChEMBL records both actions as AGONIST with direct interaction and disease efficacy.

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Partial mu opioid receptor agonist with kappa opioid receptor activity; ChEMBL records both actions as AGONIST with direct interaction and disease efficacy.
Target: CHEMBL233 (mu opioid receptor); CHEMBL237 (kappa opioid receptor)
Injury models: Other
Reported indication: Not recorded
First approval: 1981
Development stage: Not recorded
ChEMBL record: CHEMBL511142 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Buprenorphine; Temgesic; Buprenex; Butrans; Suboxone; Sublocade; Buvidal; Brixadi; Belbuca; Subutex
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04116528 ↗PHASE3completed

Trial title not recorded

Major Depressive Disorder

Enrolment: 50 · Results not recorded

NCT00000344 ↗PHASE2completed

Trial title not recorded

Opioid-Related Disorders

Enrolment: 40 · Results not recorded

NCT00000353 ↗PHASE2completed

Trial title not recorded

Opioid-Related Disorders · Substance-Related Disorders

Enrolment: 0 · Results not recorded

NCT03248947 ↗EARLY_PHASE1completed

Trial title not recorded

Opioid Use Disorder

Enrolment: 71 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29166664 ↗2017Mixed findings

Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?

RatOtherSprague-Dawley (Crl:CD(SD))Malen = 228 rats total across 12 groups, of which 184 were operated…Subcutaneous, oral and local wound irrigationBuprenorphine 0.1 mg/kg subcutaneously or 1.0 mg/kg orally…Subcutaneous drugs given during anaesthesia before incision; oral buprenorphine…

Model: Spared nerve injury: common peroneal and tibial branches of the sciatic nerve tightly ligated with 5-0 Prolene and sectioned distal to the ligation with about 2 mm of distal stump removed, sural nerve left intact

No analgesic regimen altered the development of mechanical allodynia after spared nerve injury, but the high-dose combination caused severe adverse effects including peritonitis and increased wound dehiscence, and 72-hour buprenorphine regimens reduced food intake and bodyweight gain

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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