Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury.
MouseChemical/toxinSprague-DawleyMalen = Pharmacokinetics 105 rats with 35 per group and 5 per time…IntravenousMethylprednisolone 1 mg/kg/day and 0.5 mg/kg/day as targete…Treatment started after establishing the bleomycin acute lung injury model
Model: Acute lung injury by single intratracheal bleomycin injection at 5 mg/kg for pathology, cytokine and lavage studies or 10 mg/kg for the survival study; controls received an equal volume of intratracheal saline
Lung-targeted methylprednisolone liposomes achieved higher lung drug accumulation, peak 30.8 versus 19.2 ug/g for untargeted, better histopathological improvement and lower inflammatory cytokines, and only the 1 mg/kg targeted group showed significantly higher 10-week survival, with no detectable l…
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