Association of riluzole and dantrolene improves significant recovery after acute spinal cord injury in rats.
RatSpinal cord injuryCompressionWistarMalen = 29 rats total: laminectomy plus placebo n=6, injury plus pl…Riluzole 15 min after laminectomy and dantrolene 1 hour after laminectomy
Model: Laminectomy at T12 followed by compressive trauma to induce thoracic spinal cord injury
The combination of riluzole and dantrolene produced significant locomotor recovery compared with all other groups, with more NeuN positive neurons adjacent to the injury epicentre and TUNEL staining similar to uninjured animals, indicating a synergistic reduction in apoptotic cell death
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