A Time Limit for Initiating Anti-Inflammatory Treatment for Improved Olfactory Function after Head Injury.
MouseOtherOlfactory marker protein (OMP)-tau-lacZ transgenic mice on C57BL/6 backgroundSubcutaneous injectionTreatment started at 7, 14, 28 or 42 days after nerve transection
Model: Olfactory nerve transection (NTx) as a model of post-traumatic olfactory dysfunction after head injury
Mice treated from 7 days after nerve transection had less injury-associated tissue, fewer astrocytes and macrophages and better histological and functional nerve recovery than saline controls. Treatment begun at 14, 28 or 42 days produced no significant histological or functional difference from co…
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