Block duration after spinal block and IV dexamethasone: randomized controlled trial
Postoperative Pain · Lower Limb Injury
Enrolment: 50 · Results not recorded
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Drug · Glucocorticoid receptor agonist (AGONIST; direct interaction) - taken from parent dexamethasone CHEMBL384467; no MoA record on the salt entry
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postoperative Pain · Lower Limb Injury
Enrolment: 50 · Results not recorded
Peripheral T-Cell Lymphoma, Not Otherwise Specified · Angioimmunoblastic T-cell Lymphoma
Enrolment: 34 · Results not recorded
Multiple Myeloma · Renal Impairment
Enrolment: 51 · Results not recorded
Multiple Myeloma · Relapsed/Refractory Multiple Myeloma
Enrolment: 100 · Results not recorded
Intrahepatic Cholangiocarcinoma
Enrolment: 5 · Results not recorded
Multiple Myeloma
Enrolment: 19 · Results not recorded
Multiple Myeloma
Enrolment: 7 · Results not recorded
Macular Edema
Enrolment: 200 · Results not recorded
Temporomandibular Disorder
Enrolment: 80 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Olfactory nerve transection (NTx) as a model of post-traumatic olfactory dysfunction after head injury
Mice treated from 7 days after nerve transection had less injury-associated tissue, fewer astrocytes and macrophages and better histological and functional nerve recovery than saline controls. Treatment begun at 14, 28 or 42 days produced no significant histological or functional difference from co…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Intracortical penetration injury from bilateral microdialysis probe implantation (300 micrometre outer diameter, 4 mm length) into cortical area V1/V2 at a 30 degree angle
At 6 h after insertion the distance at which microglia had a 50 per cent probability of being active fell from 177.1 micrometres with artificial cerebrospinal fluid to 93.0 micrometres with dexamethasone, with index values indicating less reactive microglia. Some atypical non-polarised microglial m…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Lithium chloride 3 meq/kg intraperitoneally about 3 hours before pilocarpine, methyl scopolamine nitrate 5 mg/kg intraperitoneally 30 minutes before, then pilocarpine hydrochloride 30 mg/kg intraperitoneally to induce status epilepticus (defined as Racine stage 3), terminated with diazepam 10 mg/kg intraperitoneally at 90 minutes plus a second 10 mg/kg dose 30 to 40 minutes later
Dexamethasone worsened outcome, with hippocampal T2 at 2 days of 55.3 ms at 10 mg/kg and 55.0 ms at 2 mg/kg versus 52.1 ms for untreated status epilepticus and 45.6 ms for controls, significantly higher piriform T2 at 2 and 4 days (p=0.01 and p=0.04), significantly lower relative hippocampal volume…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.