Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats.
RatChemical/toxinWistarMalen = n = 12 per group across five groups, 60 rats in totalOral gavage50, 100 and 200 mg/kg in 0.5% sodium carboxymethyl cellulosePretreatment for 7 consecutive days before the triptolide challenge on day 8
Model: Acute hepatotoxicity from a single intraperitoneal injection of triptolide 2 mg/kg on day 8, after 7 days of oral pretreatment
Silymarin pretreatment dose-dependently reduced triptolide-induced rises in serum ALT, AST, ALP, total cholesterol and GGT and limited hepatic necrosis and inflammatory infiltration. It restored SOD, GSH-Px, CAT and GST activities and GSH, suppressed malondialdehyde and lowered hepatic TNF-alpha, I…
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