Silibinin With Chemoradiotherapy and Maintenance Temozolomide in STAT3-Positive IDH Wild-type Glioblastoma
Glioblastoma
Enrolment: 110 · Results not recorded
Loading the evidence…
Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Glioblastoma
Enrolment: 110 · Results not recorded
Hypertension
Enrolment: 50 · Results not recorded
Knee Osteoarthritis
Enrolment: 338 · Results not recorded
Dental Plaque
Enrolment: 50 · Results not recorded
Atrial Fibrillation New Onset
Enrolment: 160 · Results not recorded
Body Dysmorphic Disorder
Enrolment: 0 · Results not recorded
Hepatitis C
Enrolment: 70 · Results not recorded
Carcinoma, Non-Small-Cell Lung
Enrolment: 42 · Results not recorded
Radiodermatitis
Enrolment: 13 · Results not recorded
Smoking
Enrolment: 21 · Results not recorded
Breast Cancer
Enrolment: 37 · Results not recorded
Head and Neck Cancer · Oral Mucositis
Enrolment: 60 · Results not recorded
Advanced Hepatocellular Carcinoma
Enrolment: 3 · Results not recorded
Tuberculosis
Enrolment: 600 · Results not recorded
Healthy
Enrolment: 32 · Results not recorded
Rheumatoid Arthritis · Psoriatic Arthritis · Psoriasis
Enrolment: 72 · Results not recorded
Decompensated Cirrhosis
Enrolment: 80 · Results not recorded
Nonalcoholic Fatty Liver Disease
Enrolment: 94 · Results not recorded
Fibrosis, Liver
Enrolment: 400 · Results not recorded
Vascular function
Enrolment: 66 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Acute hepatotoxicity from a single intraperitoneal injection of triptolide 2 mg/kg on day 8, after 7 days of oral pretreatment
Silymarin pretreatment dose-dependently reduced triptolide-induced rises in serum ALT, AST, ALP, total cholesterol and GGT and limited hepatic necrosis and inflammatory infiltration. It restored SOD, GSH-Px, CAT and GST activities and GSH, suppressed malondialdehyde and lowered hepatic TNF-alpha, I…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Restraint stress-induced acute liver injury (6 hours restraint)
Restraint stress induced severe oxidative stress and raised pro-inflammatory mediator mRNA, both significantly inhibited by silymarin. Silymarin significantly prevented acute liver injury by blocking JNK activation and subsequent apoptotic signalling, attributed at least in part to antioxidant acti…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Doxorubicin-induced cardiorenal injury
Combined ethanolic Vitis vinifera extract and silymarin restored near-normal renal and cardiac histomorphology, significantly improved creatinine, blood urea nitrogen, lipid profile and high-sensitivity C-reactive protein, and raised Nrf2 mRNA expression.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Thermal burn injury
Thermal burns were associated with extensive oxidation of polyunsaturated fatty acids in the hepatic microsomal compartment, and this oxidation was antagonised by antioxidants such as silibinin.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Whole-thorax irradiation with a single 13 Gy dose of 6 MV photons at 3.8 Gy/min, with a separate arm in mice bearing intravenously seeded Lewis lung carcinoma nodules
All irradiated mice survived to 170 days but survival fell to 40 per cent by 200 days, whereas all silibinin-treated irradiated mice survived to 200 days. Silibinin reduced bronchoalveolar lavage inflammatory cells, macrophage enlargement and collagen deposition, and did not reduce the antitumour e…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.