Cryptdin-2 predicts intestinal injury during heatstroke in mice.
MouseOtherBALB/cMalen = n = 6 per group, 60 mice in totalIntraperitoneal injection100,000 U/kgImmediately after core temperature reached 40 or 42 degrees C; tissues sampled…
Model: Heat stress model with mice held at 35.5 +/- 0.5 degrees C and 60 +/- 5% humidity until core temperature reached 40 or 42 degrees C, followed in some groups by 6 h cooling at 25 +/- 0.5 degrees C; sham controls held at 25 degrees C
Heat stress caused progressive intestinal injury with rising Chiu scores and increased serum and intestinal diamine oxidase, D-lactic acid and cryptdin-2, worsening further after 6 h of cooling in animals reaching 42 degrees C. Ulinastatin 100,000 U/kg given immediately after the core temperature r…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.