Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses.
MixedRadiationThy-1-YFPPre-administration before irradiation
Model: Whole-brain radiotherapy in Thy-1-YFP mice and irradiation of hippocampal cultures expressing enhanced green fluorescent protein; radiation dose and fractionation not stated in the retrieved text
Irradiation produced an acute increase in dendritic spines and excitatory synapses followed by a later decrease in spine and synapse density with altered spine dynamics. Memantine pre-administration prevented this radiation-induced synaptic remodelling. The authors interpret this as evidence that a…
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