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PRECLINICAL PUBLICATION · 2017

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 29109234 ↗2017Reported benefit

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury.

MouseSpinal cord injuryContusionFemaleAdministered after spinal cord injury; exact time points not stated in the retr…

Model: Spinal cord contusion injury in adult female mice; contusion force and vertebral level not stated in the retrieved text

Specialised proresolving mediator biosynthesis was not induced at the lesion site up to 2 weeks after contusion injury. Exogenous maresin 1 accelerated neutrophil clearance, reduced macrophage accumulation, lowered proinflammatory cytokines, silenced STAT and MAPK signalling and redirected macropha…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.