Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin.
RatChemical/toxinMaleSubcutaneousIndomethacin 1 mg/kg; natural prostaglandin E2 1 or 3 mg/kgStarting 5 days after acetic acid injection, once ulcers were established
Model: Gastric ulcer induced by submucosal injection of 20 per cent acetic acid (0.03 ml) at the antral-oxyntic border
Repeated indomethacin markedly delayed natural healing of acetic acid ulcers and reduced gastric mucosal prostaglandin E2 for at least 12 h after dosing. Co-administered prostaglandin E2 prevented the delay, and prostaglandin E2 at 3 mg/kg twice daily also accelerated natural healing and reduced hi…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.