Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-kappaB and HMGB1.
RatHaemorrhage/shockControlledLewisFemalen = 24 rats randomised into 3 groups50 mg/kg supplemented into Ringer's lactate resuscitation f…Given with resuscitation after 60 min of haemorrhagic shock
Model: Blunt thoracic trauma followed by haemorrhagic shock at 35 +/- 3 mmHg for 60 min and resuscitation; sham animals underwent surgical procedures only; analyses 2 h after resuscitation
Ethyl pyruvate significantly improved arterial oxygenation compared with Ringer's lactate alone after blunt thoracic trauma and haemorrhagic shock. It reduced lactate dehydrogenase and total protein in bronchoalveolar lavage fluid and lessened histological lung damage, lung TNF-alpha and polymorpho…
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