Combination therapy of human umbilical cord mesenchymal stem cells and FTY720 attenuates acute lung injury induced by lipopolysaccharide in a murine model.
MouseEndotoxin/LPSC57BL/6Femalen = n = 10 per group for oedema, injury scoring and BALF protei…hUC-MSCs intravenously via the tail vein; FTY720 intraperitoneallyhUC-MSCs in 200 ul; FTY720 0.1 mg/kg in 200 ul24 h after LPS challenge for both agents
Model: Acute lung injury induced by intratracheal instillation of Escherichia coli O55:B5 lipopolysaccharide 10 mg/kg in 50 ul under pentobarbital anaesthesia
All three treatment arms reduced CT and histological lung injury, lung injury scores, wet/dry weight ratio and bronchoalveolar lavage protein at 48 h relative to LPS plus PBS, with near-normal recovery by day 7. The combination of hUC-MSCs and FTY720 produced significantly greater reductions in lun…
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