Umbilical Mesenchymal Stem Cells in Treatment of Acute-on-Chronic Liver Failure: Phase IIb/III Seamless Adaptive Design
Acute-On-Chronic Liver Failure
Enrolment: 96 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute-On-Chronic Liver Failure
Enrolment: 96 · Results not recorded
Acute-On-Chronic Liver Failure
Enrolment: 100 · Results not recorded
Multiple Sclerosis, Relapsing-Remitting
Enrolment: 69 · Results not recorded
Alzheimer's Disease
Enrolment: 46 · Results not recorded
Ovarian Failure
Enrolment: 0 · Results not recorded
Thin Endometrium · Intrauterine Adhesion
Enrolment: 18 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Acute lung injury induced by intratracheal instillation of Escherichia coli O55:B5 lipopolysaccharide 10 mg/kg in 50 ul under pentobarbital anaesthesia
All three treatment arms reduced CT and histological lung injury, lung injury scores, wet/dry weight ratio and bronchoalveolar lavage protein at 48 h relative to LPS plus PBS, with near-normal recovery by day 7. The combination of hUC-MSCs and FTY720 produced significantly greater reductions in lun…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: 50% total body surface area full-thickness scald burn (back 12 s and abdomen 6 s in 94 degrees C water)
Mesenchymal stem cells and recombinant human TSG-6 reduced phosphorylation of P38 and JNK but not ERK, improved burn induced hypothermia and leukopenia, raised IL-10 and lowered TNF-alpha, IL-1beta and IL-6 in serum and organs, and reduced neutrophil and macrophage infiltration in liver, kidney, lu…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Acute radiation pneumonitis induced by X-ray irradiation
Rats given human umbilical cord mesenchymal stem cells before or after irradiation had better survival status and better preserved lung morphology, proliferation activity and bronchial state than irradiated controls.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by retrograde pancreatic duct injection of sodium taurocholate
UCMSCs reduced mortality from 58 percent to 10 percent when given at 0 h at 5 x 10^6 cells/kg and reduced ascites, serum amylase, pancreatic oedema and inflammatory cytokines in a time-dependent and dose-dependent manner.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.