Alpha 1-antitrypsin ameliorates ventilator-induced lung injury in rats by inhibiting inflammatory responses and apoptosis.
RatOtherMaleIntravenous
Model: Ventilator-induced lung injury from mechanical ventilation; ventilation parameters and duration not stated in the retrieved text
Mechanical ventilation caused histological lung injury with altered PaO2/FiO2 ratio, wet-to-dry weight ratio and bronchoalveolar lavage protein. Intravenous alpha 1-antitrypsin improved these parameters and reduced inflammation, with fewer BALF neutrophils, lower BALF cytokines and serum adhesion f…
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