Agmatine Modulates the Phenotype of Macrophage Acute Phase after Spinal Cord Injury in Rats.
RatSpinal cord injuryContusionSprague-Dawleyn = n = 5 per group for qRT-PCR; animal numbers for FACS and im…Intraperitoneal100 mg/kgStarted the day after spinal cord injury
Model: Thoracic contusion spinal cord injury with laminectomy of half of T9 and full T10 and a 10 g rod dropped from 25.0 mm using the MASCIS impactor, under tiletamine/zolazepam and xylazine anaesthesia
By flow cytometry agmatine did not significantly change the proportion of M1 or M2 macrophages one week after injury, although iNOS median fluorescence fell and CD206 rose non-significantly. Immunohistochemistry showed a significant rise in the M2 proportion caudal to the epicentre only, driven by…
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