Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model.
RatSpinal cord injuryContusionSprague-DawleyMale and female (both listed in MeSH; distribution not stated)Local (extradural cooling device over T6 to T10)30 plus or minus 0.5 degrees C for 5 or 8 hoursStarted 2 hours after injury
Model: Moderate thoracic contusive spinal cord injury at T8 (12.5 mm weight drop)
Both 5 and 8 hour local hypothermia improved SSEP amplitude recovery (earlier and more sustained with 8 hours), BBB locomotor scores and parenchymal preservation versus normothermia, plateauing after day 42
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