THERAPY DOSSIER · th-a16fbb523cf6

Local moderate hypothermia (30 plus or minus 0.5 degrees C)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03442608 ↗Injury indicationNAunknown

Efficacy and Safety of Long-term Therapeutic Hypothermia in Adult Patients With Poor-grade Aneurysmal Subarachnoid Haemorrhage

Hypothermia · Aneurysmal Subarachnoid Hemorrhage

Enrolment: 200 · Results not recorded

NCT00774631 ↗PHASE4terminated

Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care

Bacterial Meningitis

Enrolment: 98 · Results not recorded

NCT00878644 ↗PHASE3completed

Therapeutic Hypothermia After Pediatric Cardiac Arrest (Out of Hospital)

Cardiac Arrest

Enrolment: 295 · Results not recorded

NCT03429972 ↗PHASE2unknown

Regional Cryotherapy in Preventing Paclitaxel Induced Peripheral Neuropathy in Early and Locally Advanced Breast Cancer

Breast Cancer

Enrolment: 51 · Results not recorded

NCT05767476 ↗Phase not recordedrecruiting

Neurodevelopmental Outcome in Newborns With Hypoxic-ischaemic Encephalopathy Treated With Therapeutic Hypothermia

Encephalopathy, Hypoxic Ischemic

Enrolment: 70 · Results not recorded

NCT00500825 ↗Phase not recordedcompleted

Influence of Therapeutic Hypothermia on Resting Energy Expenditure in Patients After Cardiopulmonary Resuscitation

Cardiopulmonary Resuscitation

Enrolment: 25 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29074466 ↗2017Reported benefit

Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model.

RatSpinal cord injuryContusionSprague-DawleyMale and female (both listed in MeSH; distribution not stated)Local (extradural cooling device over T6 to T10)30 plus or minus 0.5 degrees C for 5 or 8 hoursStarted 2 hours after injury

Model: Moderate thoracic contusive spinal cord injury at T8 (12.5 mm weight drop)

Both 5 and 8 hour local hypothermia improved SSEP amplitude recovery (earlier and more sustained with 8 hours), BBB locomotor scores and parenchymal preservation versus normothermia, plateauing after day 42

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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