Effect of tendon hydrogel on healing of tendon injury.
RatOtherWistarMalen = 36 rats (bilateral paired design; 10 tendon specimens per g…Local injection at the site of injury0.05 mL hydrogel injected once at the injury siteImmediately after creation of the defect, before wound closure
Model: Bilateral full-thickness Achilles tendon defect: segment 5 mm long and 0.5 mm wide removed from calcaneus along the tendon midline
Hydrogel significantly increased ultimate failure load at 4 weeks (74.8 versus 58.4 N, P=0.02, about 28% higher) and early type I collagen content, with no significant differences at 2 or 8 weeks; the benefit was transient and matched hydrogel degradation
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.