Evidence & regulatory context
- Mechanism
- Decellularised, pepsin-digested rat tendon extracellular matrix formulated as an injectable hydrogel; a device/biomaterial with no discrete molecular entity, so no ChEMBL match (resolved=false). No human trial of a tendon-derived ECM hydrogel was found. The only ECM-hydrogel trial retrieved is NCT02305602 (VentriGel, a porcine myocardial ECM hydrogel, Phase 1, n=15, completed, post-myocardial-infarction), which is a different tissue source and indication and is therefore recorded as context only, not as a trial of this therapy.
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatOtherWistarMalen = 36 rats (bilateral paired design; 10 tendon specimens per g…Local injection at the site of injury0.05 mL hydrogel injected once at the injury siteImmediately after creation of the defect, before wound closure
Model: Bilateral full-thickness Achilles tendon defect: segment 5 mm long and 0.5 mm wide removed from calcaneus along the tendon midline
Hydrogel significantly increased ultimate failure load at 4 weeks (74.8 versus 58.4 N, P=0.02, about 28% higher) and early type I collagen content, with no significant differences at 2 or 8 weeks; the benefit was transient and matched hydrogel degradation
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
RatOtherWistarn = 36 rats, both Achilles tendons per animalInjection into the tendon injury siteAt the time of injury
Model: Bilateral full-thickness Achilles tendon injury approximately 5 mm long and 0.5 mm wide from the calcaneal insertion to the midsubstance
Ultimate failure load was significantly higher with hydrogel than saline at 4 weeks (74.8 plus or minus 11.6 N versus 58.4 plus or minus 14.2 N, p = 0.02), with no significant differences at 2 or 8 weeks and no differences in ultimate tensile stress or stiffness at any time point.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
