Alterations in the Timing of Huperzine A Cerebral Pharmacodynamics in the Acute Traumatic Brain Injury Setting.
RatTBIFluid percussionSprague-Dawleymalen = 18 injured and 13 sham rats for the injury comparison; 6 pe…Intraperitoneal0.6 mg/kg90 min after traumatic brain injury
Model: Lateral fluid percussion injury (FPI) or sham injury in anaesthetised adult rats
Traumatic brain injury reduced cortical inhibition at 90 min compared with sham (p=0.03). Huperzine A enhanced cortical inhibition after both sham injury (p=0.002) and traumatic brain injury (p=0.02), restoring inhibition lost after injury. The median time to maximum huperzine A inhibition was 46.4…
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