Drug · Acetylcholinesterase inhibitor (INHIBITOR)
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage
Enrolment: 60 · Results not recorded
Traumatic Brain Injury
Enrolment: 14 · Results not recorded
Neurosensory Disorder
Enrolment: 20 · Results not recorded
Schizophrenia · Dementia
Enrolment: 15 · Results not recorded
Epilepsy · Seizures, Epileptic
Enrolment: 60 · Results not recorded
Focal Impaired Awareness Seizures
Enrolment: 16 · Results not recorded
Cocaine Dependence · Cocaine Addiction · Cocaine Abuse · Substance Abuse
Enrolment: 72 · Results not recorded
Presbycusis · Tinnitus · Cognitive Impairment
Enrolment: 60 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Lateral fluid percussion injury (FPI) or sham injury in anaesthetised adult rats
Traumatic brain injury reduced cortical inhibition at 90 min compared with sham (p=0.03). Huperzine A enhanced cortical inhibition after both sham injury (p=0.002) and traumatic brain injury (p=0.02), restoring inhibition lost after injury. The median time to maximum huperzine A inhibition was 46.4…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Spinal cord clip compression injury (moderate static clip compression, 70 g for 60 s, at T7 level)
Huperzine A treatment significantly reduced the number of apoptotic cells (P<0.01) and necrotic cells with more normal appearing neurons compared with untreated trauma groups. BBB scores showed improved locomotor performance in the treated group relative to controls.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Simulated hypobaric hypoxia at 6,000 m in an animal decompression chamber for 5 days
Huperzine A at 0.1 mg/kg restored spatial memory, with decreased escape latency and path length and increased platform crossings and quadrant time, and significantly reduced hippocampal oxidative stress and pro-apoptotic protein expression.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
