Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases.
MouseChemical/toxinC57BL/6MaleOral10 and 20 mg/kgAdministered throughout the experimental period alongside alcohol challenge
Model: Alcohol-induced acute liver injury: five oral gavage doses of 10 mL/kg of 50% ethanol at 12 hour intervals
Capsaicin at 10 and 20 mg/kg normalised hepatic enzymes, antioxidant status, MMP levels and histological alterations after ethanol challenge
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