THERAPY DOSSIER · th-97123c3b5d44

Capsaicin

Drug · Vanilloid receptor opener (OPENER)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Vanilloid receptor opener (OPENER)
Target: CHEMBL4794
Injury models: Chemical/toxin
Reported indication: Neuropathic pain - postherpetic neuralgia (8% patch Qutenza, approved 2009) and diabetic peripheral neuropathy of the feet (TRPV1 agonist)
First approval: 2009
Development stage: Approved for PHN/neuropathic pain; SCI-neuropathic-pain use investigational
ChEMBL record: CHEMBL294199 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: ALGRX 4975; Ausanil; Axsain; Capsaicin; Capsaicina; Capsaicine; Capzasin-hp; Cntx-4975; Dolenon; NGX-4010; NGX-1998; Qutenza; Trans-capsaicin; Zacin; Zostrix
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02441660 ↗Injury indicationNAcompleted

Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain

Spinal Cord Injuries · Neuropathic Pain

Enrolment: 11 · Results not recorded

NCT00064623 ↗PHASE3completed

Dose Finding Study of NGX-4010 (Capsaicin) for Painful HIV-Associated Distal Symmetrical Polyneuropathy

HIV Infections · Peripheral Nervous System Diseases · Pain

Enrolment: 300 · Results not recorded

NCT00912262 ↗PHASE1completed

Tolerability and Effects on Epidermal Nerve Fiber Density of Capsaicin Topical Liquid NGX-1998

Pain

Enrolment: 36 · Results not recorded

NCT01673529 ↗PHASE1completed

Effects of Topical SB705498 on Capsaicin, Histamine, and Cowhage Responses in Healthy Volunteers

Dermatitis, Atopic

Enrolment: 16 · Results not recorded

NCT00677378 ↗Phase not recordedcompleted

Capsaicin-sensitive TRPV1 and TrkA Receptor Expression in Children With Retrosternal Pain

Epigastric Pain · Retrosternal Pain · Esophagitis · Gastrointestinal Symptoms

Enrolment: 77 · Results not recorded

NCT01884116 ↗NAcompleted

NSAID Patch Alone vs Combined With TENS, Heating Pad, or Topical Capsaicin in Myofascial Pain Syndrome

Myofascial Pain Syndrome of the Upper Trapezius

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29053935 ↗2017Reported benefit

Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases.

MouseChemical/toxinC57BL/6MaleOral10 and 20 mg/kgAdministered throughout the experimental period alongside alcohol challenge

Model: Alcohol-induced acute liver injury: five oral gavage doses of 10 mL/kg of 50% ethanol at 12 hour intervals

Capsaicin at 10 and 20 mg/kg normalised hepatic enzymes, antioxidant status, MMP levels and histological alterations after ethanol challenge

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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