Acute administration of oestradiol or progesterone in a spinal cord ischaemia-reperfusion model in rats.
RatIschaemia-reperfusionSpinalWistarMaleIntravenous (MeSH: infusions, intravenous)280 microgram/kg 17beta-oestradiol or 4 mg/kg progesterone30 minutes before aortic occlusion
Model: Spinal cord ischaemia-reperfusion: transient endovascular occlusion of the proximal descending thoracic aorta for 12 minutes
Neither oestradiol nor progesterone given 30 minutes before occlusion prevented or attenuated spinal cord ischaemic injury; functional scores, viable neuron counts and immunostaining did not differ between groups
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