Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats.
RatSpinal cord injuryContusionSprague-Dawleymale (female rats used for the oestrogen receptor alpha comparison)n = Total not stated; group sizes of n=3 and n=6 reported for i…Subcutaneous slow-release pellet implanted in the mid-scapular region15 mg tamoxifen pellet designed to release a constant dose…0, 6, 12 or 24 h after spinal cord injury
Model: Laminectomy followed by a moderate contusion of the thoracic (T10) spinal cord delivered with the MACSIS impactor
Tamoxifen begun immediately or at 6 h after injury improved locomotor function, increased spared white matter and improved neuronal survival. Tamoxifen reduced reactive gliosis during the chronic stage and increased Olig-2 expression. Oestrogen receptor alpha expression differed significantly betwe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.