Effects on bone mineral density of tamoxifen, letrozole and letrozole + zoledronic acid as adjuvant treatment of early breast cancer
Breast Cancer
Enrolment: 1294 · Results not recorded
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Drug · Estrogen receptor alpha modulator (MODULATOR; mixed agonist/antagonist)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Breast Cancer
Enrolment: 1294 · Results not recorded
Breast Cancer
Enrolment: 3 · Results not recorded
Breast Neoplasms
Enrolment: 257 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Laminectomy followed by a moderate contusion of the thoracic (T10) spinal cord delivered with the MACSIS impactor
Tamoxifen begun immediately or at 6 h after injury improved locomotor function, increased spared white matter and improved neuronal survival. Tamoxifen reduced reactive gliosis during the chronic stage and increased Olig-2 expression. Oestrogen receptor alpha expression differed significantly betwe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: drug-induced and chemical-induced acute liver injury produced by acetaminophen, bromobenzene, diclofenac or thioacetamide
Pretreatment with ethinylestradiol, tamoxifen and raloxifene reduced liver injury caused by several hepatotoxicants in female mice, whereas an oestrogen receptor antagonist gave no protection. Protection by tamoxifen and the associated rise in Mmd2 mRNA were lost in oestrogen receptor alpha knockou…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.