Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats.
RatSpinal cord injuryUnspecifiedSprague-Dawleymalen = 72 male rats randomly divided into 4 groupsOral, dietary interventionDietary intervention given for 2 weeks before injury
Model: Acute cervical (C5) spinal cord injury; the injury method is not specified in the abstract
All three dietary interventions significantly increased beta-hydroxybutyrate in serum and cerebrospinal fluid and inhibited spinal cord histone deacetylase activity by 31 to 43%. Acetylated histones AcH3K9 and AcH3K14 increased significantly, as did the antioxidant genes Foxo3a and Mt2 and the rela…
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