Photobiomodulation Therapy Improves Acute Inflammatory Response in Mice: the Role of Cannabinoid Receptors/ATP-Sensitive KChannel/p38-MAPK Signalling Pathway.
MouseChemical/toxinMalePlantar irradiation660 nm, 30 mW, 0.06 cm2 spot, 50 J/cm2
Model: Carrageenan-induced paw oedema, with comparison models of lipopolysaccharide and zymosan-induced inflammation
Photobiomodulation significantly inhibited carrageenan-induced paw oedema but not noxious thermal response, an effect reversed by CB1 or CB2 antagonism and dependent on ATP-dependent potassium channels and p38 MAPK. It reduced IL-6 in paw and spinal cord and restored spinal IL-10, without central c…
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