BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model.
MouseRadiationC57L/JBoth sexes (age- and sex-matched; untreated controls included in both sexes)Oral gavage200 or 400 mg/kgStarting 24 h after irradiation
Model: Whole thorax lung irradiation, single dose of 11.0 or 12.5 Gy, producing radiation pneumonitis and fibrosis
BIO 300 at 400 mg/kg orally for 4 to 6 weeks starting 24 h after whole thorax lung irradiation reduced morbidity and improved survival, correlating with reduced respiratory frequency and enhanced pause. Treated lungs showed less morphological damage and airway loss from oedema, congestion and fibro…
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