Reserpine, vagal adrenergic activity and stress-induced acute gastric mucosal injury in the rat.
RatChemical/toxinInbred strain (not further specified)Male and femalen = n = 10 per groupIntraperitonealPhenoxybenzamine or phentolamine 5, 10 or 15 mg/kg; atropin…Pre-treatment before reserpine
Model: Reserpine-induced (5 mg/kg intraperitoneally, 6 h) stress acute gastric mucosal injury in the gastric diversion rat
Reserpine produced glandular gastric lesions of vascular origin (29 +/- 2.7 mm2). Atropine (28 +/- 3 mm2) and cimetidine (27.5 +/- 2.3 mm2) were not protective. Phenoxybenzamine and phentolamine were dose-dependently protective, with complete protection at 15 mg/kg and restoration of H+ output towa…
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