THERAPY DOSSIER · th-78020400fb1b

Phenoxybenzamine and phentolamine (alpha-adrenoceptor antagonists); atropine and cimetidine also tested; vagotomy and coeliac ganglionectomy as surgical comparisons

Drug · Adrenergic receptor alpha antagonist (ANTAGONIST)

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Evidence & regulatory context

Mechanism: Adrenergic receptor alpha antagonist (ANTAGONIST)
Target: Adrenergic receptor alpha
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: 1953
Development stage: Not recorded
ChEMBL record: CHEMBL753 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Phenoxybenzamine; Fenoxibenzamina; Bensylyt; Benzylyt; Dibenylin; Dibenzyline
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05702944 ↗PHASE4recruiting

Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma

Pheochromocytoma · Paraganglioma · Adrenalectomy; Status

Enrolment: 24 · Results not recorded

NCT01379898 ↗PHASE4completed

Phenoxybenzamine vs Doxazosin for Preoperative Treatment of Pheochromocytoma (PRESCRIPT)

Pheochromocytoma

Enrolment: 134 · Results not recorded

NCT03176693 ↗PHASE3completed

Randomized Controlled Trial of Preoperative Alpha Blockade for Pheochromocytoma

Pheochromocytoma · Paraganglioma

Enrolment: 39 · Results not recorded

NCT00770705 ↗PHASE2withdrawn

Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery

Congenital Heart Disease

Enrolment: 0 · Results not recorded

NCT00569855 ↗PHASE2completed

Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

Open-heart Surgery · Cardiopulmonary Bypass

Enrolment: 785 · Results not recorded

NCT04557072 ↗Phase not recordedcompleted

Selective Versus Nonselective Alpha-blockade Prior to Pheochromocytoma Resection

Pheochromocytoma

Enrolment: 1344 · Results not recorded

NCT00620945 ↗NAterminated

Phenoxybenzamine IV to Assist High Flow Low Pressure Perfusion in Infants With CHD

Congenital Heart Surgery · Cardiopulmonary Bypass

Enrolment: 87 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2895809 ↗1987Reported benefit

Reserpine, vagal adrenergic activity and stress-induced acute gastric mucosal injury in the rat.

RatChemical/toxinInbred strain (not further specified)Male and femalen = n = 10 per groupIntraperitonealPhenoxybenzamine or phentolamine 5, 10 or 15 mg/kg; atropin…Pre-treatment before reserpine

Model: Reserpine-induced (5 mg/kg intraperitoneally, 6 h) stress acute gastric mucosal injury in the gastric diversion rat

Reserpine produced glandular gastric lesions of vascular origin (29 +/- 2.7 mm2). Atropine (28 +/- 3 mm2) and cimetidine (27.5 +/- 2.3 mm2) were not protective. Phenoxybenzamine and phentolamine were dose-dependently protective, with complete protection at 15 mg/kg and restoration of H+ output towa…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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