Effect of Tendon Stem Cells in Chitosan/beta-Glycerophosphate/Collagen Hydrogel on Achilles Tendon Healing in a Rat Model.
RatOtherSprague-DawleyMalen = 114 rats in total; 96 used for the healing experiment, rand…Local implantation, injected around the injury site with a 1 ml syringe300 microlitres of hydrogel containing tendon stem cells; c…Immediately after creation of the defect, following closure of the skin incision
Model: Achilles tendon defect: the central one third of the left Achilles tendon (10 mm x 1 mm) was excised from the myotendinous junction to the calcaneus
Tendon stem cells combined with the chitosan/beta-glycerophosphate/collagen hydrogel significantly improved histology scores, increased collagen type I and scleraxis, reduced collagen type III and increased ultimate load and stiffness at 4 and 6 weeks versus control, hydrogel and cells alone. Tendo…
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